I. PURPOSE. To ensure safe evidence based utilization of stress ulcer prophylaxis to prevent upper . ASHP therapeutic guidelines on stress ulcer prophylaxis. ASHP Therapeutic Guidelines on Stress Ulcer Prophylaxis. ASHP Commission on Therapeutics and approved by the ASHP Board of Directors on November 14, . Stress Ulcer Prophylaxis in the ICU effects associated with the use of stress ulcer .. ASHP is currently updating their guidelines, with.

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Patients with neurologic injury or traumatic brain injury have been seen as a risk factor, but the above studies included these patients and did not show a change in the rates of CSGIB. McClave S, Martindale R, Vanek Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient.

In addition, the most widely used agents for SUP, proton pump inhibitors PPIhave been associated with an increasing number of adverse effects, including myocardial infarction, Clostridium difficile infectionosteoporosis and ventilator associated pneumonia [ 5 ]. Nutrition has been recognized as not just adjunctive therapy to provide exogenous fuels but as treatment to help attenuate the metabolic response ulceer stress and prevent cellular injury [ 9 ]. As the incidence of significant bleeding decreases and the knowledge about prophylaxis-related adverse events increases, it is necessary to revisit current clinical practice.

We No Longer Need to Stress Ulcer Prophylaxis in the Critically Ill

In conclusion, the prevalence of clinically significant bleeding has decreased from 1. Furthermore, enteral nutrition may independently provide prophylaxis against stress gastropathy by increasing intragastric pH, similar to medication therapies, and providing cytotoxin protection [ 145 ].

Select your language of interest to view the total content in your interested language. Additionally, the recognition of the important of enteral nutrition early in the ICU stay encourages mesenteric perfusion and reduces risk for development of ischemic damage. Proc Bayl Med Cent This bleeding is associated with significant morbidity and mortality; therefore, it is considered standard of care to provide stress ulcer prophylaxis SUP to patients who are risk of stress gastropathy [ 2 ].


Study protocol for a randomised controlled trial. Can’t read the image? Since this study’s publication more than two decades ago, the incidence of clinically significant gastrointestinal bleeding secondary to stress gastropathy has significantly declined.

In addition, the most widely used agents for prophylaxis have been associated with an increasing number of adverse effects, including myocardial infarction, Clostridium difficile infection, osteoporosis and ventilator associated pneumonia. Patients with risk factors for stress gastropathy who demonstrate no evidence of splanchnic hypoperfusion may not benefit from receiving stress ulcer prophylaxis and tolerance of enteral nutrition may be used as a surrogate marker for adequate perfusion.

Overall there is a lack of high quality data supporting stress ulcer prophylaxis in the modern era. All Published work is licensed under a Creative Commons Attribution 4. Patient selection for minimizing the use of SUP is a very important parameter that has been discerned throughout the years. References Stollmann N, Metz D Pathophysiology and prophylaxis of stress ulcer in intensive care unit patients.

Tolerance of enteral nutrition may be the surrogate marker for adequate perfusion as seen in the studies discussed above. J Parenter Enteral Nutr A pilot randomized clinical trial and meta-analysis.

J Burn Care Res May 28, ; Published date: Another major change in practice over the past decades is the promotion of early enteral nutrition in the buidelines ill. Contemporary studies have failed to replicate significant rates of gastrointestinal bleeding, likely in part due to these advances in care.

A landmark trial in identified the most significant risk factors for stress gastropathy as mechanical ventilation for greater than 48 h and primary coagulopathy.

Intensive Care Med Recent studies, including a pilot randomized trial, are questioning the necessity of pharmacologic prophylaxis in the modern era, with undetectable rates of gastrointestinal bleeding in enrolled patients.

Finally, a pilot randomized control trial was recently conducted by Cook and colleagues to evaluate the safety of withholding SUP. Mohebbi L, Hesch K Stress ulcer prophylaxis in the intensive care unit.

J Crit Care J Crit Care Med The main cause of stress gastropathy in the intensive care unit ICU is mucosal ischemia due to splanchnic hypoperfusion, which may be caused by shock or changes in intra-thoracic pressure i.

The increase in recognition and early treatment of sepsis has likely impacted a reduction in stress ulcers through avoidance of hypoperfusion [ 6 ]. Neither study evaluated the role of early enteral nutrition. Visit for more related articles at Journal of Intensive and Critical Care.


Prevalence, pathology and association with adverse outcomes. The collection of data guidelinds lend credence to the theory that, with advances in clinical practice, there may no longer be benefit to SUP in our highest risk patients admitted to the surgical and medical ICU.

Surviving Sepsis Campaign Bundles. These patients have been evaluated in several studies that have concluded prkphylaxis enteral nutrition was able to decrease overt bleeding and no additional pharmacologic prophylaxis was needed [ 1415 ]. Major practice changes, including early aggressive fluid resuscitation and development of dynamic markers for volume status, have reduced the likelihood for prolonged hypoperfusion states.

Randomized double-blind exploratory study.

We No Longer Need to Stress Ulcer Prophylaxis in the Critically Ill | Insight Medical Publishing

Preventing stress gastropathy has been a mainstay in the management lrophylaxis critically ill patients for decades. Raff T, Germann G, Hartmann B The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient.

Overall there is a lack of high quality data supporting SUP in the modern era. Much of the current literature evaluates patients in whom mechanical ventilation is the primary risk factor for stress gastropathy.

May 31, s. Prophylactic pantoprazole demonstrated no benefit to mechanically ventilated patients who received enteral nutrition [ 11 ]. Crit Care Med Although this study was not powered to determine a difference in CSGIB based on contemporary rates of bleeding, it is hypothesis generating, and larger scales studies are prophylzxis enrolling [ 1213 ]. Tolerance of enteral nutrition in the ICU is dependent on adequate gut perfusion, thereby demonstrating that the patient is not experiencing splanchnic ischemia.

One of these advancements is early goal directed therapy EGDTwhich promotes aggressive early fluid resuscitation in septic patients.