Equilibrio de Gibbs-DonnanFisiología general y biofísicaLic. NutriciónKarla Keesoon Irais Carrera ➀ ➁ ➂ ➃ ➄ ➅ ➆. ➇. Español: Equilibrio de Gibbs – Donnan. Date. Source, Own work. Author, Biezl. Other versions. Image: Equilibrio de Gibbs Donnan. El líquido corporal se divide en intracelular y extracelular. El líquido intracelular se subdivide en dos compartimientos: intravascular.

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ATP pumps maintain a negative membrane potential donnn though negative charges leak across the membrane; this action establishes a chemical and electrical gradient. The increased osmotic pressure forces water to flow into the cell and tissue swelling occurs.

The electric potential arising between two such equilibio is called the Donnan potential. Annals of the New York Academy of Sciences. A contribution to physical-chemical physiology].

Donnan effect on chloride ion distribution as a determinant of qeuilibrio fluid composition that allows action potentials to spread via fast sodium channels. By using this site, you agree to the Terms of Use and Privacy Policy. Brain tissue swelling, equolibrio as cerebral oedema, results from brain injury and other traumatic head injuries that can increase intracranial pressure ICP.

When tissue cells are in a protein-containing fluid, the Donnan effect of the cytoplasmic proteins is equal and opposite to the Donnan effect of the extracellular proteins. This page was last edited on 28 Octoberat Because there is a difference in concentration of ions on either side of the membrane, the pH may also differ when protons are involved.


To neutralize the negative charges within the cell, cations flow in, which increases the osmotic pressure inside relative to the outside of the cell. The opposing Donnan effects cause chloride ions to migrate inside the cell, increasing the intracellular chloride concentration.

Efecte de Gibbs-Donnan

The presence of a charged impermeant ion for example, a protein on one side of a membrane will result in an asymmetric distribution of permeant charged ions. I n vivoion balance does not equilibriate at the proportions that would be predicted by the Gibbs-Donnan model, because the cell cannot tolerate the attendant large influx of water. Physical chemistry Colloidal chemistry.

Because small cations are attracted, but are not bound equilirbio the proteins, small anions will cross capillary walls away from the anionic proteins more readily than small cations.

From Wikipedia, the free encyclopedia. Some ionic species can pass through the barrier while others cannot.

File:Gibbs-donnansvg – Wikimedia Commons

In many instances, from ultrafiltration donnab proteins to ion exchange chromatography, the pH of the buffer adjacent to the charged groups of the membrane is different from the pH of the rest of the buffer solution. Negatively charged molecules within cells create a fixed charge density, which increases intracranial pressure through the Donnan effect.

Retrieved from ” https: The Donnan effect may explain why some red blood cells do not have active sodium pumps; the effect relieves the osmotic pressure of plasma proteins, which is why sodium pumping is less important for maintaining the cell volume. The solutions may be gels or colloids as well as solutions of electrolytesand as such the phase boundary between gels, or a gel and a liquid, can also act as a selective barrier.


Fixed negative charge and the Donnan effect: The membrane voltage will become zero, but the chemical gradient ddonnan still exist. The negative charge in the cell and ions outside the cell creates a thermodynamic potential; if damage occurs to the brain and cells lose their membrane integrity, ions will rush into the cell to balance chemical and electrical gradients that were previously established. When the charged groups are positive acidicthen they will repel protons so that the pH will be higher than the surrounding buffer.

The Gibbs—Donnan effect also known as the Donnan’s effectDonnan lawDonnan equilibriumor Gibbs—Donnan equilibrium is a equlibrio for the behaviour of charged particles near a semi-permeable membrane that sometimes fail to distribute evenly across the two sides of the membrane.


Ein Beitrag zur physikalisch-chemischen Physiologie” [The theory ee membrane equilibrium and membrane potential in the presence of a non-dialyzable electrolyte. The Donnan equilibrium is prominent in the triphasic model for articular cartilage proposed by Mow and Lai, as well as in electrochemical fuel cells and dialysis.

Archived from the original on Note that Sides 1 and 2 are no longer in osmotic equilibrium i. Views Read Edit View history.