Heterociklična jedinjenja su ciklična jedinjenja koja pored ugljenika sadrže u strukturi prstena jedan ili više atoma nekih drugih elemenata-. Start studying Heterociklična jedinjenja (Petočlana). Learn vocabulary, terms, and more with flashcards, games, and other study tools. izvor: Wikipedia. Stranice: Poglavlja: Heterociklična Jedinjenja (2 prstena), Heterociklična Jedinjenja (3 prstena), Heterociklična Jedinjenja (4 ili više.

Author: Tojalar Vile
Country: Central African Republic
Language: English (Spanish)
Genre: Health and Food
Published (Last): 22 November 2010
Pages: 237
PDF File Size: 10.53 Mb
ePub File Size: 16.2 Mb
ISBN: 140-2-20022-683-2
Downloads: 74002
Price: Free* [*Free Regsitration Required]
Uploader: Zolor

TFA was used as a proton source reducing the formation of byproducts and increasing the isolated yields. Stadlbauer, Synthesis of benzo-halogenated 4-hydroxy-2 1H -quinolones, J.

tiofen – Heterociklična jedinjenja

One such review was published by Pemberton et al. In addition to these products a derivative of 2-hydroxyphenylcyanopyridones was also obtained Table 1, entry Separate each e-mail address with a semicolon Subject line: Loupy, Jedibjenja synthesis of 4-aryl substituted 5-alkoxycarbonylmethyl-3,4-dihydropyridones under microwave irradiation, Tetrahedron Lett. Westman, The impact of microwave-assisted organic chemistry on drug discovery, Drug Discov.

At the end of the review several examples of microwave synthesis of other 2-pyridone based compounds ring fused W-substituted 2-pyridones are given. Feng, Microwave assisted synthesis of pyridone derivatives, Chin.

The mechanism of the reaction is complex and involves Jedinjebja reaction, addition of Michael or Perkin reaction, whereby the degree of enolyzation of dioxo compounds determines the participation of Michael addition [30,31]. Mikrotalasne sinteze se ubrajaju medu metode koje postuju principe takozvane “zelene hemije” sto predstavlja razlog vise za ovakvo izvodjenje sinteza.


A derivative of N-phenylpyridone, perampanel Figure 1dacts as a non-competitive and selective antagonist of [alpha]-aminohydroxymethylisoxazolepropionic acid receptor, and improves motor symptoms in animal models of Parkinson’s disease [18]. The synthesis of 3,5-dicyanopyridone is carried out in aqueous solution starting from aldehydes and malononitrile in the presence of sodium hydroxide as a base. Synthesis of substituted 3-cyanopyridones at positions 4 and 6 was also carried out using microwave irradiation type jedinienja [57], and under conventional conditions [58] Figure 8.

N-substituted 4,6-dimethylcyanopyridones were obtained from acetylacetone and the corresponding W-substituted cyanoacetamide using conventional and microwave synthesis in the presence of piperidine as a catalyst.

Shen, The 2-pyridone antibacterial agents: Hultgren, Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation, Nat.

This method cannot be applied in cases where an electron-acceptor group e. In comparison heterocillicna conventional synthesis, microwave reactor synthesis shows that the reaction is 5 or more times faster using microwave technique.


Oikawa, Biosynthetic studies on the antibiotics PF Visser, Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions, Tetrahedron Lett. The six-member heterocyclic rings containing nitrogen e. MarkovicDanijela V. This type of synthesis involves the reaction of phenylazo carbonyl compounds and cyanoacetamide hetdrociklicna KOH as base and ethanol as solvent in a dedicated microwave reactor. This issue requires special attention and is beyond the scope of this paper.

In this paper, the synthesis of 2-pyridones as well as 2-pyridone-based compounds, such as 2-quinolones, using microwave assisted organic chemistry is reviewed.


Heterociklično jedinjenje

We will point out the advantages of microwave assisted synthesis in comparison to conventional heating. Konvencionalni nacin izvodenja organskih sinteza podrazumeva zagrevanje spoljasnjim izvorima toplote pri cemu se toplota prenosi kondukcijom, sto predstavlja spor i neefikasan metod prenosa energije, jer zavisi od toplotne provodljivosti materijala, pa je temperatura reaktora veca od temperature reakcione smese.

It should be noted that 4-pyridone, isomer of 2-pyridone, due to mesogenic properties, is used in the synthesis of liquid crystals [19]. Zhu, One-pot synthesis of pyridones and related compounds under microwave irradiation in water, Jiamusi Daxue Xuebao Ziran Kexueban 28 Tehnolosko-metalurski fakultet Univerziteta u Beogradu, Karnegijeva 4, p. Twieg, Aromatic nucleophilic substitution with 4-hydroxypyridine, Tetrahedron Lett. Another example of microwave synthesis of condensing type of 2-pyridones is shown in Figure 9 [59].

Microwave synthesis was performed using a conventional microwave oven in the absence of solvent.

Copy the Bookmark Jedinjenjs. Listen Larger documents may require additional load time. However, the use of microwave irradiation has a number of advantages over both conventional methods: Synthesis of 5-phenylazo-4,6-dimethylcyanopyridones and 5-phenylazo-4,6-diphenylcyanopyridone are shown in Figure 7.

Sestoclana heterociklicna jedinjenja koja sadrze azot npr.